Mafusol and its combination with REXOD as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemia

Introduction: The search for and development of new highly active medications their combinations the appropriate direction action remains an urgent problem due to complications diabetes mellitus, especially burdened with atherosclerosis, including skin vascular lesions.
 Materials methods: acute toxicity, histoprotective dermatoprotective effects mafusol, rexod, alprostadil were studied in male rats normoglycemia alloxan complicated by exogenous hypercholesterolemia.
 Results: combination mafusol rexod is less toxic than mafusol. In arteriovenous insufficiency tail, ischemia fold flap, (6.25, 12.5 25.0 mg/kg terms fumarate), (0.01 0.02 mg/kg) (6.25 0.01 have significant histoprotective, dermatoprotective, hypoglycemic lipid-lowering effects, both hypercholesterolemia. Alprostadil (10 its a effect.
 Discussion: Rexod reduces toxicity effect and, greater extent, may be associated increased microhemocirculation, antihypoxic properties activation energy processes skin, normalization carbohydrate lipid metabolism diabetes, hypercholesterolemia, reserve capacity antioxidant system, possibly ability reduce blood viscosity improve rheological blood. increases activity latter.
 Conclusion: Combinations can recommended clinical study as agents treating traumatic injuries mellitus atherosclerosis.